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According to the Los Angeles Times  the unhealthful but popular practice of yo-yo dieting may have serious ramifications on the body, a study finds, which may make those who eat this way more vulnerable to packing on the pounds.

In the study, released Tuesday in the Journal of Neuroscience, mice were randomly assigned to a calorie-restricted diet, in which they ate 75% of the average amount of calories designed to produce a 10% to 15% weight loss, or to a regular diet with no such restrictions.

Under stressful situations the dieting mice had escalated amounts of the stress hormone corticosterone, and exhibited symptoms of depression. There was a transformation in the DNA of the mice as well&–genes that control eating and stress had changed, and those changes remained after the mice ate enough to go back to their normal, higher weights.

While under stressful circumstances the dieting mice ate more fatty foods than mice that had not dieted.

Most of us have known that yo-yo dieting is not effective. Dr. O'Toole explains to his patients that weight fluctuations can also result in loose and lax skin which will not tighten as weight is lost. What this means is that patients may need an abdominoplasty to tighten skin in the abdomen. They may need a breast lift if there is significant sagging in the breast. If significant weight has been lost in the face, a  facelift maybe needed. The best way to avoid a significant amount of loose and lax skin after weight loss is to lose weight slowly. Once the weight is lost, of course the best results will be seen in patients who maintain their weight loss.

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